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COATESTTM APCTM RESISTANCE


An APTT-based assay for the detection of the APC resistance phenotype, i.e. the poor anticoagulant response to activated protein C (APC). The test result (APC ratio) gives an estimation of the anticoagulant function in vivo and provides information on the thrombotic risk associated with inherited and acquired APC resistance.



Measurement Principle

Plasma is incubated with the APTT reagent for a standard period of time. Coagulation is initiated by the addition of CaCl2 in the absence and presence of APC and the time for clot formation is recorded.



Reagents and their stability when opened

CaCl2
1x8 ml
1 week
15-25°C
1 month
2-8°C
APTT reagent
1x16 ml
1 week
15-25°C
1 month
2-8°C
APC/CaCl2
4x2 ml
8 hours
15-25°C
5 days
2-8°C
3 months
-20°C

Determinations

Automated methods
80-160

Part Number: 82 2643 63